Blar i forfatter "Stocker, Martin"

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    • Analysis of Antibiotic Exposure and Early-Onset Neonatal Sepsis in Europe, North America, and Australia 

      Giannoni, Eric; Dimopoulou, Varvara; Klingenberg, Claus Andreas; Navér, Lars; Nordberg, Viveka; Berardi, Alberto; El Helou, Salhab; Fusch, Gerhard; Bliss, Joseph M.; Lehnick, Dirk; Guerina, Nicholas; Seliga-Siwecka, Joanna; Maton, Pierre; Lagae, Donatienne; Mari, Judit; Janota, Jan; Agyeman, Philipp K A; Pfister, Riccardo; Latorre, Giuseppe; Maffei, Gianfranco; Laforgia, Nicola; Mózes, Eniko; Størdal, Ketil; Strunk, Tobias; Stocker, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-23)
      <p><b> IMPORTANCE</b> Appropriate use of antibiotics is life-saving in neonatal early-onset sepsis (EOS), but overuse of antibiotics is associated with antimicrobial resistance and long-term adverse outcomes. Large international studies quantifying early-life antibiotic exposure along with EOS incidence are needed to provide a basis for future interventions aimed at safely reducing neonatal ...

    • Association of use of the neonatal early-onset sepsis calculator with reduction in antibiotic therapy and safety: A systematic review and meta-analysis 

      Achten, Niek B.; Klingenberg, Claus; Benitz, William E.; Stocker, Martin; Schlapbach, Luregn J.; Giannoni, Eric; Bokelaar, Robin; Driessen, Gertjan J.A.; Brodin, Petter; Uthaya, Sabita; van Rossum, Annemarie M.C.; Plötz, Frans B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-03)
      <i>Importance</i> - The neonatal early-onset sepsis (EOS) calculator is a clinical risk stratification tool increasingly used to guide the use of empirical antibiotics for newborns. Evidence on the effectiveness and safety of the EOS calculator is essential to inform clinicians considering implementation.<p> <p><i>Objective</i> - To assess the association between management of neonatal EOS ...

    • Culture-negative early-onset neonatal sepsis - at the crossroad between efficient sepsis care and antimicrobial stewardship 

      Klingenberg, Claus; Kornelisse, Rene F.; Buonocore, Giuseppe; Maier, Rolf F.; Stocker, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-09)
      Sepsis is a leading cause of mortality and morbidity in neonates. Presenting clinical symptoms are unspecific. Sensitivity and positive predictive value of biomarkers at onset of symptoms are suboptimal. Clinical suspicion therefore frequently leads to empirical antibiotic therapy in uninfected infants. The incidence of culture confirmed early-onset sepsis is rather low, around 0.4–0.8/1000 term ...

    • Less is more: Antibiotics at the beginning of life 

      Stocker, Martin; Klingenberg, Claus Andreas; Navér, Lars; Nordberg, Viveka; Berardi, Alberto; el Helou, Salhab; Fusch, Gerhard; Bliss, Joseph M.; Lehnick, Dirk; Dimopoulou, Varvara; Guerina, Nicholas; Seliga-Siwecka, Joanna; Maton, Pierre; Lagae, Donatienne; Mari, Judit; Janota, Jan; Agyeman, Philipp K. A.; Pfister, Riccardo; Latorre, Giuseppe; Maffei, Gianfranco; Laforgia, Nichola; Mózes, Enikő; Størdal, Ketil; Strunk, Tobias; Giannoni, Eric (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-27)
      Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver for antibiotic overtreatment early in life. Bias (a systemic deviation towards overtreatment) and noise ...

    • Stratification of Culture-Proven Early-Onset Sepsis Cases by the Neonatal Early-Onset Sepsis Calculator: An Individual Patient Data Meta-Analysis 

      Achten, Niek B.; Plötz, Frans B.; Klingenberg, Claus; Stocker, Martin; Bokelaar, Robin; Bijlsma, Merijn; Giannoni, Eric; van Rossum, Annemarie M.C.; Benitz, William E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-03)
      Objectives - To provide a comprehensive assessment of case stratification by the Neonatal Early-Onset Sepsis (EOS) Calculator, a novel tool for reducing unnecessary antibiotic treatment.<p> <p>Study design - A systematic review with individual patient data meta-analysis was conducted, extending PROSPERO record CRD42018116188. Cochrane, PubMed/MEDLINE, EMBASE, Web of Science, Google Scholar, and ...